Andrew R Marks Selected Research

Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)

1/2022	Alzheimer's-like signaling in brains of COVID-19 patients.
12/2021	Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity.
11/2021	RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation.
2/2021	Alzheimer's-like remodeling of neuronal ryanodine receptor in COVID-19.
1/2021	Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation.
11/2020	Reply to 'Mechanisms of ryanodine receptor 2 dysfunction in heart failure'.
10/2020	Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
1/2020	Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation.
1/2020	Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.
11/2018	Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure.

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Andrew R Marks Research Topics

Disease

35	Heart Failure 01/2022 - 01/2002
15	Cardiac Arrhythmias (Arrythmia) 10/2021 - 01/2002
14	Polymorphic catecholergic ventricular tachycardia 10/2020 - 01/2002
12	Cardiac Sudden Death (Sudden Cardiac Arrest) 06/2008 - 01/2002
8	Muscular Diseases (Myopathy) 11/2021 - 03/2003
6	Heart Diseases (Heart Disease) 01/2022 - 12/2003
5	Disease Progression 01/2022 - 01/2003
5	Muscle Weakness 11/2021 - 03/2009
5	Cardiomyopathies (Cardiomyopathy) 01/2021 - 04/2002
5	Ventricular Tachycardia 10/2020 - 01/2006
5	Neoplasms (Cancer) 01/2019 - 04/2012
4	Atrial Fibrillation 10/2021 - 04/2005
4	Myocardial Infarction 12/2010 - 07/2005
3	Alzheimer Disease (Alzheimer's Disease) 02/2021 - 01/2017
3	Muscular Dystrophies (Muscular Dystrophy) 01/2021 - 03/2009
3	Sudden Death 05/2015 - 06/2004
3	Fatigue 09/2013 - 03/2003
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 05/2012 - 03/2009
3	Hypertrophy 01/2012 - 04/2002
2	COVID-19 01/2022 - 02/2021
2	Atrophy 01/2020 - 01/2016
2	Neoplasm Metastasis (Metastasis) 01/2017 - 11/2015
2	Muscular Atrophy (Muscle Atrophy) 01/2017 - 01/2016
2	Hypertension (High Blood Pressure) 01/2016 - 09/2013
2	Mitochondrial Diseases (Mitochondrial Disease) 07/2015 - 05/2015
2	Cardiomegaly (Heart Hypertrophy) 03/2012 - 01/2012
2	Malignant Hyperthermia 07/2010 - 01/2002
2	Central Core Myopathy (Central Core Disease) 07/2010 - 01/2002
1	Post-Acute COVID-19 Syndrome 01/2022
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2021
1	Emery-Dreifuss Muscular Dystrophy (Scapuloperoneal Muscular Dystrophy) 01/2021
1	Laminopathies 01/2021
1	Huntington Disease (Huntington's Disease) 10/2020
1	Bone Resorption 01/2017
1	Breast Neoplasms (Breast Cancer) 01/2017
1	Arthralgia (Joint Pain) 01/2017
1	Cachexia 01/2017
1	Neuroblastoma 01/2017
1	Lung Neoplasms (Lung Cancer) 11/2015
1	Camurati-Engelmann Syndrome (Progressive Diaphyseal Dysplasia) 11/2015
1	Glucose Intolerance 05/2015
1	Diabetes Mellitus 05/2015
1	Syncope (Fainting) 02/2015
1	Mitochondrial Myopathies (Mitochondrial Myopathy) 10/2014
1	Thrombophilia 09/2014
1	Asthma (Bronchial Asthma) 12/2013

Drug/Important Bio-Agent (IBA)

61	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2022 - 01/2002
31	CalciumIBA 11/2021 - 01/2002
9	Proteins (Proteins, Gene)FDA Link 01/2017 - 04/2002
6	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 05/2013 - 01/2002
5	tacrolimus binding protein 1BIBA 05/2006 - 05/2003
4	Tacrolimus Binding Protein 1A (FKBP12)IBA 09/2013 - 04/2002
4	Sirolimus (Rapamycin)FDA Link 03/2013 - 07/2003
3	Phosphotransferases (Kinase)IBA 05/2013 - 01/2003
3	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 05/2013 - 04/2004
3	beta Adrenergic ReceptorsIBA 05/2004 - 05/2003
2	Pharmaceutical PreparationsIBA 02/2021 - 01/2016
2	Metoprolol (Toprol-XL)FDA LinkGeneric 11/2018 - 05/2003
2	CatecholaminesIBA 11/2018 - 05/2004
2	Adrenergic Antagonists (Antiadrenergic Agents)IBA 01/2016 - 01/2010
2	Glucose (Dextrose)FDA LinkGeneric 05/2015 - 05/2012
2	MTOR InhibitorsIBA 03/2013 - 04/2012
2	DystrophinIBA 05/2012 - 03/2009
2	Ion Channels (Ion Channel)IBA 07/2010 - 11/2007
2	Tacrolimus Binding Proteins (FKBP)IBA 01/2010 - 05/2003
2	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 10/2006 - 10/2005
2	K201 compoundIBA 07/2005 - 06/2004
2	Adrenergic Agents (Adrenergic Drugs)IBA 01/2004 - 12/2003
1	Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)IBA 01/2022
1	Adenosine Triphosphate (ATP)IBA 11/2021
1	SodiumIBA 10/2021
1	Lamin Type A (Lamin A)IBA 01/2021
1	LaminsIBA 01/2021
1	NADPH Oxidase 2IBA 11/2019
1	LipidsIBA 11/2019
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 11/2019
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2019
1	Flecainide (Tambocor)FDA LinkGeneric 11/2018
1	Biomarkers (Surrogate Marker)IBA 11/2018
1	salicylhydroxamic acid (SHAM)IBA 01/2017
1	Diphosphonates (Bisphosphonates)IBA 01/2017
1	Estrogen ReceptorsIBA 01/2017
1	Aromatase InhibitorsIBA 01/2017
1	Amyloid (Amyloid Fibrils)IBA 01/2017
1	MyostatinIBA 01/2017
1	UbiquitinIBA 01/2017
1	Ligases (Synthetase)IBA 01/2017
1	Calcineurin InhibitorsIBA 01/2016
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2016
1	NADPH Oxidase 4IBA 11/2015
1	Transforming Growth Factors (Transforming Growth Factor)IBA 11/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2015
1	Insulin (Novolin)FDA Link 05/2015
1	AntioxidantsIBA 10/2014
1	Acetylcholine (Acetylcholine Chloride)FDA Link 09/2014
1	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 12/2013
1	rottlerinIBA 12/2013

Therapy/Procedure

9	Therapeutics 01/2022 - 05/2002
1	Artificial Respiration (Mechanical Ventilation) 01/2016
1	Mechanical Ventilators (Ventilator) 01/2016